HCID 20255111, compound → HCID 20255186, compound

Participants

Reaction Steps

After the addition of a total of 5 g of palladium-on-carbon catalyst (5%), a solution of 2.95 g of crude 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[4-(trifluoromethyl)-thiazol-2-yl]-phenoxy]-2-propanol in 80 ml of methanol is hydrogenated at 60° and a pressure of 4 bar until the absorption of hydrogen has ceased, the reaction product partly precipitating out of the solution. The suspension is diluted with 50 ml of dioxan/methanol, heated and filtered through a filter aid. The filtrate is freed of solvent in a rotary evaporator and the residue is recrystallised twice from methanol, yielding 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[4-(trifluoromethyl)-thiazol-2-yl]-phenoxy]-2-propanol having a melting point of 202°-203°.

Provenance & Evidence