HCID 70492998, compound → HCID 20255176, compound

Participants

Reaction Steps

A solution of 5.2 g of 1-[4-(1,6-dihydro-1-methyl-6-oxo-2-pyridyl)-phenoxy]-3-[2-(3-carbamoyl-4-hydroxyphenoxy)-N-benzylethylamino]-2-propanol in 100 ml of methanol is hydrogenated under normal conditions in the presence of 1 g of palladium-on-carbon catalyst (5%). The hydrogenated mixture is filtered with suction, the filtrate is concentrated to dryness by evaporation and the residue is washed with ethyl acetate. Recrystallisation from isopropanol yields pure 1-[4-(1,6-dihydro-1-methyl-6-oxo-2-pyridyl)-phenoxy]-3-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-2-propanol having a melting point of 148°-150°.

Provenance & Evidence