反应详情

A slurry of 41.1 g of 6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinolinecarboxylic acid ethyl ester in 250 ml of dry tetrahydrofuran was chilled to 0° and treated dropwise over 30 minutes with 62.8 ml of 3.5 M sodium bis-(2-methoxyethoxy)aluminum hydride in toluene solution. After stirring at 0° for three hours, 60 ml of saturated aqueous sodium sulfate solution was cautiously added and the mixture was stirred until granular. The supernatant solution was decanted, the residue was extracted with warm methylene chloride, and the combined organic solutions were evaporated in vacuo. The residue was dissolved in methylene chloride, washed with water, dried over sodium sulfate, and concentrated. Crystallization from methylene chloride/ethyl acetate provided 26.7 g of 6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinoline methanol as a white solid, mp 140°-146°.

1. stirringthe mixture was stirred until granular
2. customThe supernatant solution was decanted
3. extractionthe residue was extracted with warm methylene chloride
4. customthe combined organic solutions were evaporated in vacuo
5. dissolutionThe residue was dissolved in methylene chloride
6. washwashed with water
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated
9. customCrystallization from methylene chloride/ethyl acetate