Ethyl Acetate → HCID 131714456, compound

Participants

Reaction Conditions

Reaction Steps

1-DL-Iodoethyl ethyl carbonate (22 g) was added dropwise to a solution of sodium 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate (syn isomer) (15 g) in N,N-dimethylacetamide (120 ml) at 5°-7° C., and the mixture was stirred at 5° C. for 30 minutes. To the reaction mixture was added ethyl acetate (200 ml), followed by filtration. The filtrate was washed with water and an aqueous sodium chloride, and then dried over magnesium sulfate. After removal of the solvent, the residue was washed with ethyl acetate and dried in vacuo to give DL-1-ethoxycarbonyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate (syn isomer) (7.4 g), mp 126°-130° C.

Provenance & Evidence