Hydrochloric Acid → HCID 131714461, compound

Participants

Reaction Steps

To a solution of DL-1-ethoxycarbonyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate (syn isomer) (1 g) in a mixture of ethyl acetate (50 ml) and ethanol (2 ml) was added concentrated hydrochloric acid (0.3 ml) under ice-cooling, and the mixture was stirred for 10 minutes at 0°-3° C. To the solution was added diisopropyl ether (50 ml), and the resulting precipitate was collected by filtration, washed with ethyl acetate and air-dried to give DL-1-ethoxycarbonyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (0.8 g).

Provenance & Evidence