Benzhydrylamine → HCID 20253232, compound

Participants

Reaction Steps

19.5 g of 2A and 29 g of benzhydrylamine in acetonitrile were stirred and refluxed for 48 hours. The resulting mixture was cooled, filtered free of insoluble amine salt and the filtrate evaporated to dryness. The residue, which was a complex mixture of product, was partially purified using a column of silica gel and petroleum ether/ethyl acetate as the eluent. The first fast-running products to emerge were collected and evaporated to dryness, leaving the benzyl ester of 1-diphenylmethyl-2-carboxy-3-ethylazetidine (2B) as the major component (65% by NMR) of the crude residual mixture.

Provenance & Evidence