HCID 13604096, compound → HCID 13604097, compound

HRID 638144Notes

Reaction equation

HRID 638144 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([CH2:11][CH3:12])[C:6]=2[CH:5]=[C:4]2[CH2:13][CH:14]([C:16]([O:18]CC)=[O:17])[O:15][C:3]=12.O1CCCC1.CCCCCC>C(O)C.O>[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([CH2:11][CH3:12])[C:6]=2[CH:5]=[C:4]2[CH2:13][CH:14]([C:16]([OH:18])=[O:17])[O:15][C:3]=12

Participants

5

Reactant 2

HCID 13604096HCID 13604096, compoundHCID 21883165Tetrahydrofuran hexane

Product 1

HCID 13604097HCID 13604097, compoundYield 74.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Ester 7b was dissolved in minimal absolute ethanol and treated with excess alcohol potassium hydroxide at room temperature for 20 minutes, then diluted with water. Work-up as in the previous example and recrystallization from tetrahydrofuran/hexane gave white crystals, m.p. 213°-215° C., in 74.8% yield. Anal. (C12H10ClNO4) C,H,N,Cl.

Workup

  1. customgave white crystals, m.p. 213°-215° C.

Sources & evidence

ORD record
ord-5245b1a2d5024a02b74875c5e045be79
Source dataset
uspto-grants-1985_12
Patent number
US04560558

Reaction notes

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