HCID 131713508, compound → HCID 53879827, compound

Participants

Reaction Steps

A solution of the diester product from part (a) in methanol is added to a 10% palladium on carbon catalyst and the resulting mixture is shaken in a Parr hydrogenation apparatus for several hours. The catalyst is filtered off and the methanol is stripped from the filtrate. The crude product is chromatographed on silica gel to yield 1-[[ethyl[[[(2,2-dimethyl-1-oxopropoxy)methoxy](4-phenylbutyl)phosphinyl]methyl]amino]carbonyl]-L-proline.

Provenance & Evidence