反应详情

The intermediate 3-(4-methoxyphenyl)-1-methyl-3-oxo-1-propenamine was prepared as follows: A mixture containing 106 g of 1-(4-methoxyphenyl)-1,3-butanedione, 500 ml of methanol and 200 ml of concentrated aqueous ammonium hydroxide was allowed to stand at room temperature for 4 hours and then chilled in a refrigerator. The separated crystalline product was collected, washed with ether and dried at 90°-95° C. to yield 93.7 g of 3-(4-methoxyphenyl-1-methyl-3-oxo-1-propenamine, m.p. 126°-128° C.

1. temperaturechilled in a refrigerator
2. customThe separated crystalline product was collected
3. washwashed with ether
4. customdried at 90°-95° C.