反应详情

A mixture containing 50 g of 5-(4-methoxybenzoyl)-6-methyl-2(1H)-pyridinone, 400 ml of p-dioxane and 40 ml of bis(dimethyamino)-t-butoxymethane was refluxed with stirring for 5 and 1/2 hours. The reaction mixture was allowed to cool and the separated crystalline product was collected, washed with ethanol and dried in a vacuum oven at 80°-85° C., to yield 65.8 g of 6-[2-(dimethylamino)ethenyl]-5-(4-methoxybenzoyl)-2(1H)-pyridinone, m.p. 216°-218° C.

1. temperaturewas refluxed
2. temperatureto cool
3. customthe separated crystalline product was collected
4. washwashed with ethanol
5. customdried in a vacuum oven at 80°-85° C.