Acetic Anhydride → HCID 20253653, compound

Participants

Reaction Steps

To a stirred mixture containing 6.57 g of 5-(3-aminophenyl)-1,6-naphthyridin-2(1H)-one dihydrochloride monohydrate and 63 ml of pyridine was added dropwise over a period of 5 minutes 4.8 ml of acetic anhydride. The resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated on a rotary evaporator to dryness. The residue was slurried with water; and, the solid was collected, washed with water and dried in a vacuum oven at 90° C. to yield 5.4 g of 5-(3-acetylaminophenyl)-1,6-naphthyridin-2(1H)-one monohydrate, m.p. 258°-262° C.

Provenance & Evidence