反应详情

温度

50 °C

A Parr shaker was charged with 10.0 g (46.23 mmole) of 1-benzyl-4-(1-hydroxyethyl)-2-methylimidazole, 60 ml of methanol and 2.0 g of 5% palladium-on-carbon (50% water). Hydrogen gas was introduced to 30 psi (2.04 atmospheres), the mixture heated to 50° C. and shaken for 16 hours. It was cooled to 30° C., filtered through diatomaceous earth and the filter cake washed with 10 ml of methanol. Evaporation of the combined filtrate and wash under reduced pressure gave 6.44 g (97% yield) of the title product as an oil.

1. temperatureIt was cooled to 30° C.
2. filtrationfiltered through diatomaceous earth
3. washthe filter cake washed with 10 ml of methanol
4. customEvaporation of the combined filtrate
5. washwash under reduced pressure