HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-[2-(4-Chlorophenyl)-4-quinolinyl]-4-piperidinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-[2-(4-Chlorophenyl)-4-quinolinyl]-4-piperidinecarboxylic acid ethyl ester | HCID 13603906 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[2-(4-Chlorophenyl)-4-quinolinyl]-4-piperidinecarboxylic acid | HCID 13603907 | 100.4% |
Reaction Steps
A mixture of 1.5 g (3.8 mmol) of 1-[2-(4-chlorophenyl)-4-quinolinyl]-4-piperidinecarboxylic acid ethyl ester, 2.7 ml of 3N aqueous sodium hydroxide, and 50 ml of ethanol was heated on a steam bath for 0.5 hr. It was then cooled, acidified with acetic acid, and diluted with water to give 1.4 g of product, mp 245°-247°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04560692 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-e3aa70b7e4df4b3dab8329ec19606d95 |
| Source note | uspto-grants-1985_12 |