Ethyl 2-aminobenzoate → HCID 178515604, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 16.52 g (0.1 mol) of ethyl o-aminobenzoate, 15.46 g (0.1 mol) of p-choroacetophenone, and 250 ml of diphenyl ether was carefully added 18.67 g of aluminum chloride. This mixture was heated under reflux for 2 hr and then let cool to 60° C. The solids were collected and washed with 2×100 ml of toluene. These solids were triturated twice with a mixture of 500 ml of 6N hydrochloric acid and 50 ml of acetone. Each time the solids were collected they were washed with 100 ml of 6N hydrochloric acid, 3×100 ml of water, and 2×50 ml of acetone. There was obtained 22.34 g of the above-named product, mp 327-330.

Provenance & Evidence