反应详情

温度

160 °C

A mixture of 5.1 g (21 mmole) of 4-chloro-2-(4-chlorophenyl)quinoline, prepared as in Example 1(a), 6.2 g (42 mmole) of N-methylisonipecotamide, and 10 g of phenol was stirred and heated in an oil bath at 160° C. for 3.5 hr. It was then cooled and diluted with 100 ml of water. Crystallization was induced by scratching, warming and the addition of a small amount of ethanol. The solid was collected and washed with ether to give 7.0 g of crude product. Recrystallization from 150 ml of butanol gave 4.6 g of product, mp 251°-255° dec.

1. temperatureIt was then cooled
2. customCrystallization
3. temperaturewarming
4. additionthe addition of a small amount of ethanol
5. customThe solid was collected
6. washwashed with ether
7. customto give 7.0 g of crude product
8. customRecrystallization from 150 ml of butanol