Thionyl Chloride → 2-(4-Fluorophenyl)-4-quinolinecarbonyl chloride

HRID 638270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 638270
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([C:18]([OH:20])=O)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([C:18]([Cl:23])=[O:20])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 7231632-(4-Fluorophenyl)quinoline-4-carboxylic acid

Produkt 1

HCID 202536642-(4-Fluorophenyl)-4-quinolinecarbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 16.5 g of 2-(4-fluorophenyl-4-quinolinecarboxylic acid, 100 ml of thionyl chloride, and 50 ml of toluene was stirred and heated under reflux for 4 hr. The reaction mixture was the concentrated in vacuo, the residue was treated with more toluene, and the mixture again concentrated n vacuo. The residue was washed with ether to give 16 g of the above-named compound as a yellow solid.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux for 4 hr
  3. concentrationconcentrated in vacuo
  4. additionthe residue was treated with more toluene
  5. washThe residue was washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-a31b5dd447234858bee177556b390d6f
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04560692

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