反应详情

A mixture of 16.5 g of 2-(4-fluorophenyl-4-quinolinecarboxylic acid, 100 ml of thionyl chloride, and 50 ml of toluene was stirred and heated under reflux for 4 hr. The reaction mixture was the concentrated in vacuo, the residue was treated with more toluene, and the mixture again concentrated n vacuo. The residue was washed with ether to give 16 g of the above-named compound as a yellow solid.

1. temperatureheated
2. temperatureunder reflux for 4 hr
3. concentrationconcentrated in vacuo
4. additionthe residue was treated with more toluene
5. washThe residue was washed with ether