4-Piperidinecarboxamide → HCID 13603916, compound

HRID 638273Notes

Reaction equation

HRID 638273 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.[NH:19]1[CH2:27][CH2:26][CH:22]([C:23]([NH2:25])=[O:24])[CH2:21][CH2:20]1>>[C:13]1([C:4]2[CH:3]=[C:2]([N:19]3[CH2:27][CH2:26][CH:22]([C:23]([NH2:25])=[O:24])[CH2:21][CH2:20]3)[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=3)[N:5]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 37724-PiperidinecarboxamideHCID 136038964-Chloro-6-fluoro-2-phenylquinoline

Product 1

HCID 13603916HCID 13603916, compound

Procedure

Reaction of 4-chloro-6-fluoro-2-phenylquinoline and isonipecotamide in a manner similar to that of Example 4(c) gave the named compound as off-white prisms, mp 230°-233°, after recrystallization from ethanol.

Sources & evidence

ORD record
ord-2bbdb7e1a2854df7910c50161f7a5fc6
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

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