Phenol → HCID 13603925, compound

Participants

Reaction Steps

A mixture of 2.02 g (7 mmol) of 4,6-dichloro-2-(4-methylphenyl)quinoline, 1.6 g (12 mmol) of isonipecotamide, 5 g of phenol, and small amounts of sodium iodide and copper powder were stirred and heated at 160° for 4 hr. The reaction mixture was then diluted to 50 ml with water and made alkaline by the addition of concentrated ammonium hydroxide. The addition of ethyl acetate and ether induced the crystallization of 2.7 g of crude damp product. mp 260°-265°. The above-named compound was obtained as white needles, mp 265°-267° dec on recrystallization from ethanol.

Provenance & Evidence