4-Piperidinecarboxamide → 1-[6-Chloro-2-(4-fluorophenyl)-4-quinolinyl]-4-piperidinecarboxamide

HRID 638292Notes

Reaction equation

HRID 638292 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:3]=1.[NH:20]1[CH2:28][CH2:27][CH:23]([C:24]([NH2:26])=[O:25])[CH2:22][CH2:21]1>C(O)C>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[CH:3]=[C:2]2[N:20]1[CH2:28][CH2:27][CH:23]([C:24]([NH2:26])=[O:25])[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 37724-PiperidinecarboxamideHCID 136039014,6-Dichloro-2-(4-fluorophenyl)quinoline

Product 1

HCID 136039261-[6-Chloro-2-(4-fluorophenyl)-4-quinolinyl]-4-piperidinecarboxamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The named compound was made in a manner analogous to that of Example 4(c) using 4,6-dichloro-2-(4-fluorophenyl)quinoline and isonipecotamide as starting materials. It was obtained as white needles, mp 250°-252° dec on recrystallization from ethanol.

Sources & evidence

ORD record
ord-2e6eb83baf1a4212a025cef130785342
Source dataset
uspto-grants-1985_12
Patent number
US04560692

Reaction notes

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