Phenol → HCID 13603931, compound

Participants

Reaction Steps

A mixture of 2.0 g of 4-chloro-2-(4-fluorophenyl)-6-methylquinoline, 1.88 g (10 mmol) of isonipecotamide, and 4 g of phenol was stirred and heated in an oil bath at 165°-170° for 2 hr. It was then cooled and diluted with water. Crystallization was induced by the addition of ethanol and scratching. The solid was collected and washed with ether to give 1.9 g of crude product, mp 264°-271° dec. Recrystallization from pyridine gave the titled product as off-white prisms, mp 275°-277° dec.

Provenance & Evidence