反应详情

A mixture of 3.2 g of 4-chloro-6-methyl-2-(4-methylphenyl)quinoline, 3.06 g (24 mmol) of isonipecotamide, and 6 g of phenol was stirred and heated in an oil bath at 160° for 4 hr. It was then cooled and diluted with water. Crystallization was induced by the addition of ethanol and scratching. The solid was collected and washed with ether to give 3.18 g of crude product. Recrystallization from n-butanol gave off-white prisms, mp 242°-244° dec.

1. temperatureheated in an oil bath at 160° for 4 hr
2. temperatureIt was then cooled
3. customCrystallization
4. additionwas induced by the addition of ethanol
5. customThe solid was collected
6. washwashed with ether