反应详情

温度

-50 °C

Methanol (100 ml) containing 2.5 ml water is cooled to -50° C. and 3.07 g of sodium borohydride (81.2 mmole) is added with stirring. After 5 minutes, ethyl 1-(2-acetoxyethyl)-4-bromopyrrole-2-glyoxalate (8.9 g -26.7 mmole) is dissolved in 40 ml methanol and added at a rate such that the reaction temperature does not exceed -40° C. After 1 hour at this temperature, 50% aqueous acetic acid is added until the solution is weakly acidic. The methanol is then removed in vacuo, 100 ml ethyl acetate is added to the residue, and the organic phase is washed well with saturated salt solution and then dried over sodium sulfate. The solvent is removed in vacuo and the residue is immediately crystallized, at low temperature (dry ice-acetone bath), from ether. The ethyl 1-(2-acetoxyethyl)-4-bromopyrrole-2-glycolate thus obtained (6.0 g, 67%) exhibits a m.p. of 59° C. but is unstable and is be stored in an evacuated vessel at -10° C.

1. additionadded at a rate such that the reaction temperature
2. customdoes not exceed -40° C
3. customThe methanol is then removed in vacuo, 100 ml ethyl acetate
4. additionis added to the residue
5. washthe organic phase is washed well with saturated salt solution
6. dry with materialdried over sodium sulfate
7. customThe solvent is removed in vacuo
8. customthe residue is immediately crystallized, at low temperature (dry ice-acetone bath), from ether