Sodium Hydroxide → sodium 5-(4-vinylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

HRID 638315Notes

Reaction equation

HRID 638315 reaction equation
[CH:1]([C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1)=[CH2:2].[OH-].[Na+:23]>CO>[CH:1]([C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1)=[CH2:2].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 134870625-(4-vinylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

Product 1

HCID 23671914sodium 5-(4-vinylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 300 mg of 5-(4-vinylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in pb 5 ml of methanol is added 1 molar equivalent of sodium hydroxide, in the form of a 0.1 N solution. The solvent is taken up in 2 ml of methanol, followed by precipitation with ether, to yield crude sodium 5-(4-vinylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate which can be crystallized from ethyl acetate-hexane.

Workup

  1. customfollowed by precipitation with ether

Sources & evidence

ORD record
ord-68614ae4708e41f7b3f1a67e434a1f39
Source dataset
uspto-grants-1985_12
Patent number
US04560699

Reaction notes

Loading…