Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Dibromopropanoyl chloride | HCID 86790 | — |
| Reactant | 5-Methyl-1,3-dioxan-5-amine | HCID 13563594 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13563595 | HCID 13563595 | — |
Reaction Steps
Five and nine-tenths grams (g) (0.05 mole) of 5-methyl-5-amino-1,3-dioxane, 3.2 g (0.04 mole) of 50% sodium hydroxide, 8 milliliters (ml) of water and 55 ml of methylene chloride were combined in a reaction flask. The mixture was cooled to -10° C. Ten g (0.04 mole) of 2,3-dibromopropionyl chloride were added dropwise. The reaction mixture was stirred for 2 hours and then vacuum stripped. The product was recrystallized in ethanol/water. Yield was 8.7 g of 5-methyl-5-(2',3'-dibromopropionyl)amino-1,3-dioxane. m.p.=115°-119° C. Structure was confirmed by NMR spectroscopy.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04561876 |
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| Source dataset | uspto-grants-1985_12 |
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| ORD ID | ord-8dacf152e51441619a48d79346fa4559 |
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| Source note | uspto-grants-1985_12 |
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