Water → HCID 13563598, compound

Participants

Reaction Steps

Five and two-tenths g (0.04 mole) of 5-ethyl-5-amino-1,3-dioxane, 3.2 g (0.04 mole) of 50% sodium hydroxide, 10 ml of water, and 90 ml of methylene chloride were combined in a reaction flask. The mixture was cooled to below 35° C. Eight and two-tenths g (0.04 mole) of 2-bromo-3chloropropionyl chloride were added dropwise. The mixture was stirred for 1/2 hour, filtered, dried over magnesium sulfate, and vacuum stripped. Yield was 10.8 g of 5-(2'-bromo-3'-chloropropionyl) amino-5-ethyl-1,3-dioxane. m.p.=95°-109° C. Structure was confirmed by NMR.

Provenance & Evidence