反应详情

温度

20 °C

34.2 g of 2-difluoromethoxyphenylsulfonyl isocyanate and 19.7 g of 2-amino-4-chloro-6-methyl-pyrimidine are stirred in 40 ml of dioxane for 3 hours at 90°-100° C. The solution is then cooled to 20° C., filtered, and concentrated to about 1/4 of its volume. After addition of ether, 32.9 g of N-(2-difluoromethoxyphenylsulfonyl)-N'-(4-chloro-6-methyl-pyrimidin-2-yl)urea crystallise from the residue.

1. filtrationfiltered
2. concentrationconcentrated to about 1/4 of its volume
3. additionAfter addition of ether, 32.9 g of N-(2-difluoromethoxyphenylsulfonyl)-N'-(4-chloro-6-methyl-pyrimidin-2-yl)urea
4. customcrystallise from the residue