Oxalyl chloride → (2R)-2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride

Participants

Reaction Steps

To a solution of (R)-2-[4-(4-trifluoromethylphenoxy)phenoxy]-propanoic acid (1.62 g., 4.96 mm), ether (20 ml) and dimethylformamide (about 2 drops) is added slowly oxalyl chloride (0.8 ml., 2 eq.). After addition of oxalyl chloride, the reaction mixture is stirred at room temperature for one hour. The mixture is then concentrated to give the acid chloride, (R)-2-[4-(4-trifluoromethylphenoxy)phenoxy]propanoyl chloride.

Provenance & Evidence