Tetrahydrofuran → HCID 57188762, compound

Participants

Reaction Steps

A mixture of ethyl 2-formyl-1-cyclopropanecarboxylate (55 g, 0.39 moles) and formylmethylenetriphenylphosphorane (117.7 g, 0.39 moles) in tetrahydrofuran (600 ml) is refluxed for 40 hours. The solvent is removed under reduced pressure. The residue is triturated with ether/hexane (1:1) and filtered. The filtrate is evaporated, dissolved in ether/petroleum ether and filtered through a column of silica gel. The solvent is stripped from the filtrate to give a dark oil. The oil is distilled under reduced pressure to give the product as a clear colorless oil (52.1 g, 80%), b.p. 105°-113° C. (2.0 mm).

Provenance & Evidence