1-Piperazinecarboxylic acid, ethyl ester → HCID 22047956, compound

Participants

Reaction Steps

A mixture of 48.6 g (0.31 moles) of m-methoxybenzyl chloride, 49.0 g (0.31 moles) of ethyl N-piperazinocarboxylate, 250 ml of isopropyl alcohol and 35 ml of 10N sodium hydroxide was heated at reflux for 18 hours. The reaction mixture was evaporated in vacuo and gave an oil. The oil was Kugelrohr distilled bp 106° C./0.025 mm of mercury and gave 87.3 g of 4-[(3-methoxyphenyl)methyl]-1-piperazinecarboxylic acid, ethyl ether as an oil.

Provenance & Evidence