Acetic Anhydride → HCID 178474502, compound

HRID 638539Notes

Reaction equation

HRID 638539 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)[NH:4][N:3]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:7]([C:6]1[C:2]([NH:1][C:22](=[O:24])[CH3:23])=[N:3][NH:4][C:5]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][CH2:10]1)#[N:8]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 1785104933-Amino-5-(4-benzyl-1-piperazinyl)-4-pyrazolecarbonitrile

Product 1

HCID 178474502HCID 178474502, compound

Procedure

A 2.82 g (0.01 mole) amount of 3-amino-5-(4-benzyl-1-piperazinyl)-4-pyrazolecarbonitrile (prepared as described in Example 8) was added to 50 ml of acetic anhydride with stirring. After nearly complete solution a heavy precipitate was formed. The mixture was stirred for 18 hours at room temperature beneath a drying tube containing a desicant.

Workup

  1. customAfter nearly complete solution a heavy precipitate was formed
  2. stirringThe mixture was stirred for 18 hours at room temperature beneath a drying tube
  3. additioncontaining a desicant

Sources & evidence

ORD record
ord-ef9fa71f3ff948c1933fc1a29fe11f05
Source dataset
uspto-grants-1985_12
Patent number
US04562189

Reaction notes

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