Formaldehyde → HCID 70406044, compound

Participants

Reaction Steps

Acetic anhydride (70 ml) was added to a solution of dimethylamine hydrochloride (12.7 g) in 37% aqueous solution (10.5 ml) of formaldehyde at 80° C. To the solution was added 5-propionylbenzothiazolone (21.5 g) and the resultant mixture was stirred at the same temperature for 2 hours. After the solvent was evaporated in vacuo, the residue was treated with a mixture of saturated aqueous solution of sodium bicarbonate and ethyl acetate. Insoluble powder was collected by filtration to give 5-(3-dimethylamino-2-methylpropionyl)benzothiazolone (12.5 g) as light red-violet powder.

Provenance & Evidence