Sulfuric Acid → HCID 13537597, compound

Participants

Reaction Steps

To a mixture of 8.8 g of 2-(3-benzoylisoxazol-5-yl)ethanol, in 1 liter of CH2Cl2, a few crystals of tetra-n-butylammonium hydrogen sulfate and 150 ml of 9M H2SO4 was added 11.9 g (41 mmol) of pulverized K2Cr2O7. The resulting mixture was stirred at room temperature for 1.5 hour. After allowing the mixture to settle, it was decanted from the unreacted dichromate. The aqueous phase was extracted with CH2Cl2, and the organics were washed with water and brine, and dried over MgSO4. Concentration gave a wet solid which was triturated with cyclohexane and collected to give 7.1 g of a solid. Recrystallization from toluene gave 4.0 g (43%) of a solid, m.p. 108°-110°.

Provenance & Evidence