Sulfuric Acid → HCID 13576494, compound

Participants

Reaction Steps

A solution of [3-(4-fluorobenzoyl)-1,2,4-oxadiazol-5-yl]acetonitrile (5.0 g) in 98% H2SO4 (50 ml) was stirred at room temperature for 3 hours. The resulting solution was added slowly to a liter of ice water with mechanical stirring. The precipitated solid was collected by filtration and washed with water (5×300 ml) and cold isopropanol (3×150 ml). The amide was dried in vacuum to yield 5.2 g (96%) of a powder, m.p. 197°-199°.

Provenance & Evidence