Hydrochloric Acid → HCID 13809948, compound

Participants

Reaction Steps

A mixture of 9.2 g of (3-benzoyl-1,2,4-oxadiazol-5-yl)acetamide in 300 ml isopropanol was saturated with HCl gas. The resulting mixture was warmed to 70° and maintained there for 11 hours. The resulting cooled mixture was filtered and diluted with 400 ml water. Extraction with Et2O (3×300 ml), washing the organics with a saturated NaHCO3 solution, drying over MgSO4, filtration and concentration gave 10.1 g of an oil. Purification of 9.8 g of this oil by high pressure liquid chromatography with 20% hexane/CH2Cl2 used as an eluent gave 7.0 g (64%) of an oil.

Provenance & Evidence