HCID 13809951, compound → HCID 13576500, compound

Participants

Reaction Steps

A solution of isopropyl[3-(4-fluorobenzoyl)-1,2,4-oxadiazol-5-yl]acetate (6.2 g) in 97% H2SO4 (40 ml) was stirred at room temperature for 15 minutes. The resulting solution was added slowly to a liter of ice water with mechanical stirring. The precipitated solid was collected by filtration and washed with water (5×300 ml). Drying under vacuum gave 4.4 g of a powder. Recrystallization from 25% hexane/acetone gave 2.5 g (47%) of crystals, m.p. 146°-148°.

Provenance & Evidence