Sulfuric Acid → HCID 13576502, compound

Participants

Reaction Steps

To a flask containing 7.0 g of isopropyl [3-(4-toluoyl)-1,2,4-oxadiazol-5-yl]acetate was added 50 ml of cold concentrated sulfuric acid. This mixture was swirled and stirred for 10 minutes. The resulting solution was poured gradually into one liter of ice water with mechanical stirring to precipitate the product. The solid was collected by filtration, washed with water and dried in vacuo at room temperature. Recrystallization from acetone/hexane gave 3.3 g (56%) of a solid, m.p. 140°-141°.

Provenance & Evidence