Water → HCID 13343193, compound

Participants

Reaction Steps

3.4 g (0.02 mole) of 4-chlorothieno[2,3-d]pyrimidine, 3.8 g (0.02 mole) of 2-(4-allyl-2-methylphenoxy)ethylamine and 2 g (0.02 mole) of triethylamine were dissolved in 50 ml of benzene, and the solution was heated under reflux for 6 hours. At the end of this time, water was added to the reaction mixture, after which it was extracted with benzene. The extract was dried over anhydrous sodium sulphate and the solvent was distilled off, after which the residue was subjected to column chromatography through silica gel, eluted with a 9:1 by volume mixture of benzene and ethyl acetate, to give 5.4 g (yield 83%) of the desired Compound No. 8, in the form of pale yellow crystals melting at 97°-99° C.

Provenance & Evidence