Sodium Hydroxide → HCID 13537649, compound

Participants

Reaction Conditions

Reaction Steps

Hexahydro-2-oxocyclopenta[b]pyrrole-6-acetic acid methyl ester (3aα, 6β, 6aα), 2.2 g (0.011 m), is treated with 11 ml of 1N sodium hydroxide solution with stirring at 50° C. for 15 minutes. The reaction mixture is extracted with diethyl ether and the agueous layer is passed through a Dowex-acid column. Concentration of the eluate followed by filtration of the crystals yields hexahydro-2-oxocyclopenta[b]-pyrrole-6-acetic acid (3aα, 6β, 6aα) with a melting point of 186°-189° C.

Provenance & Evidence