Sodium Hydroxide → HCID 13537649, compound

HRID 638596Notes

Reaction equation

HRID 638596 reaction equation
C[O:2][C:3](=[O:14])[CH2:4][CH:5]1[CH:9]2[NH:10][C:11](=[O:13])[CH2:12][CH:8]2[CH2:7][CH2:6]1.[OH-].[Na+]>>[O:13]=[C:11]1[NH:10][CH:9]2[CH:5]([CH2:4][C:3]([OH:14])=[O:2])[CH2:6][CH2:7][CH:8]2[CH2:12]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 13537632HCID 13537632, compound

Product 1

HCID 13537649HCID 13537649, compound

Conditions

Temperature
50 °C

Procedure

Hexahydro-2-oxocyclopenta[b]pyrrole-6-acetic acid methyl ester (3aα, 6α, 6aα), 2.2 g (0.011 m) is treated with 11 ml of 1N sodium hydroxide solution with stirring at 50° C. for 15 minutes. The reaction mixture is extracted with diethyl ether and the aqueous layer is passed through a Dowex-acid column. Concentration of the eluate followed by filtration to collect the crystalline product yields hexahydro-2-oxocyclopenta[b]pyrrole-6-acetic acid (3aα, 6α, 6aα) with a melting point of 230°-232° C.

Workup

  1. extractionThe reaction mixture is extracted with diethyl ether
  2. filtrationConcentration of the eluate followed by filtration
  3. customto collect the crystalline product

Sources & evidence

ORD record
ord-fe74e895e0424f30bdea4c804dbf5695
Source dataset
uspto-grants-1985_12
Patent number
US04562195

Reaction notes

Loading…