Imidazole → HCID 54480835, compound

Participants

Reaction Conditions

Reaction Steps

64.9 g (0.94 mole) of imidazole and 129.7 g (0.94 mole) of potassium carbonate are dissolved in 1,300 ml of toluene. 173.9 g (0.47 mole) of 1-bromo-1-(4-chlorophenylthio)-5-chloro-3,3-dimethyl-2-pentanone in 360 ml of toluene are added dropwise to this mixture at 80° C. The reaction mixture is subsequently stirred at 90° C. for 15 hours and is cooled, and the inorganic residue is filtered off with suction. The filtrate is washed with water, dried over sodium sulphate and concentrated. The residue is recrystallized from diethyl ether. 61.4 g (40.8% of theory) of 4-chlorophenylthio-(imidazol-1-yl)-(3,3-dimethyl-tetrahydrofuran-2-ylidene)-methane of melting point 134° C. are obtained.

Provenance & Evidence