反应详情

A mixture of 3-chloro-4-methylbenzonitrile (4.0 g, 26.39 mmol), formic acid (72 ml, 75% v/v) and nickel aluminum alloy (50/50, 4.8 g) was stirred and heated under reflux for 2 h. The reaction mixture was then filtered hot through Hyflo, and the residue was washed well with hot ethanol. The filtrate was concentrated under reduced pressure to yield a sticky solid. Distillation of this solid afforded 3-chloro-4-methylbenzaldehyde as a colourless oil, b.p. 73°-74°/0.8 mmHg.

1. temperatureheated
2. temperatureunder reflux for 2 h
3. filtrationThe reaction mixture was then filtered hot through Hyflo
4. washthe residue was washed well with hot ethanol
5. concentrationThe filtrate was concentrated under reduced pressure
6. customto yield a sticky solid
7. distillationDistillation of this solid