HCID 13287881, compound → HCID 70410391, compound

HRID 638615Notes

Reaction equation

HRID 638615 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5](/[CH:15]=[CH:16]/[C:17]([OH:19])=[O:18])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1.[H][H]>C(O)C.[Pd]>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

5

Reactant 2

HCID 13287881HCID 13287881, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70410391HCID 70410391, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of (E)-3-[3-chloro-4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid hydrochloride (0.07 g) and 5% palladium on barium sulphate (0.01 g) in ethanol was stirred under an atmosphere of hydrogen until the theoretical amount of hydrogen had been consumed. The catalyst was then filtered off (Hyflo) and the reaction mixture was concentrated to affored a colourless oil. N.M.R. spectroscopy of the product showed that it was consistent with the proposed structure.

Workup

  1. customhad been consumed
  2. filtrationThe catalyst was then filtered off (Hyflo)
  3. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-87e3f6f37a4c4088b3d5358af18e1d9a
Source dataset
uspto-grants-1985_12
Patent number
US04562199

Reaction notes

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