反应详情

温度

25 °C

Into a 100-mL round-bottom flask, was placed a solution of [4-bromo-3-(2,2,2-trifluoroethyl)phenyl]methanol (800 mg, 2.97 mmol, 1.00 equiv) in dichloromethane (20 mL), PCC (1.3 g, 6.03 mmol, 2.00 equiv). The resulting solution was stirred for 3 h at 25° C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:30-1:10). This resulted in 700 mg (88%) of 4-bromo-3-(2,2,2-trifluoroethyl)benzaldehyde as yellow oil.

1. customInto a 100-mL round-bottom flask, was placed
2. concentrationThe resulting mixture was concentrated under vacuum
3. customThis resulted in 700 mg (88%) of 4-bromo-3-(2,2,2-trifluoroethyl)benzaldehyde as yellow oil