HCID 54019290, compound → HCID 70410509, compound

Participants

Reaction Steps

A mixture of 1-[3-(3-chloro-4-ethoxycarbonylphenyl)prop-2-enyl]imidazole (0.09 g) in hydrochloric acid (3 ml, 6M) was stirred and heated under reflux for 3 h. The reaction mixture was concentrated under reduced pressure, and toluene (10 ml) was added and the reaction mixture re-concentrated. Repetition of the toluene/concentration procedure three times afforded a white solid which was recrystallised from ethyl acetate/ethanol/ether to give 1-[3-(4-carboxy-3-chlorophenyl)prop-2-enyl]imidazole hydrochloride hemihydrate as a white crystalline solid, m.p. 247°-249°.

Provenance & Evidence