Hydrochloric Acid → HCID 56633302, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.57 g of (1R,2S,3S)-2-benzyloxymethyl-3-butyl-1-(2-tetrahydropyranyloxy)cyclopentane (prepared in Reference Example 6), 50 ml of tetrahydrofuran and 25 ml of 2N hydrochloric acid was stirred for 2.5 hrs at 40° C. The mixture was extracted with 150 ml of diethyl ether, and the extract was washed with an aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride successively, dried over anhydrous magnesium sulphate, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of cyclohexane and ethyl acetate (3:1) as eluent to give 4.31 g of the title compound having the following physical characteristics, in a 66.4% yield.

Provenance & Evidence