4-Toluenesulfonyl chloride → HCID 56624501, compound

Participants

Reaction Steps

To a solution cooled with ice, of 94 mg of (1RS,3S)-3-butylcyclopentan-1-ol (prepared in Reference Example 11) in 2 ml of pyridine, 260 mg of p-toluenesulphonyl chloride was added, and the mixture was stirred for 30 min. at the same temperature and for 5 hrs at room temperature. The reaction solution was poured into ice-water. The mixture was extracted with a mixture of pentane and diethyl ether (1:1). The extract was washed with water, dried over magnesium sulphate, and concentrated under ambient pressure at 50° C. to give 190 mg of the title compound having the following physical characteristic.

Provenance & Evidence