1,1-Dichloroacetone → 2-(4-(Chloromethyl)-4-hydroxy-2-thiazolin-2-yl)guanidine hydrochloride

Participants

Reaction Steps

60.0 kg of dichloroacetone is dissolved in 550 ml of acetone. After cooling the solution to -5°~-7° C., 55.8 kg of (aminoiminomethyl)thiourea [amidinothiourea] is added to the solution under cooling portionwise at one hour intervals each time in a 10 kg amount of amidinothiourea. The mixture is stirred continuously for 5 days below 0° C. The resultant precipitates are collected by filtration, and washed with 50 l of acetone to provide 111.6 kg of the desired compound. This material can be used as the starting material for the next process.

Provenance & Evidence