Pyridine → 2-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid

Participants

Reaction Steps

The aminoamide (24.25 mmol) is added over a two hour period to a solution of 2,3-quinolinedicarboxylic anhydride (20.06 mmol) in pyridine (100 mL) while maintaining the reaction mixture at room temperature. The mixture is allowed to stir at room temperature for one-half hour. Analysis of the isomer distribution of the reaction products by high performance liquid chromatography shows an 8.9/1 ratio of the desired 2-carbamoyl-3-quinolinecarboxylic acid.

Provenance & Evidence