反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 110 °C
PROCEDURE
实验过程
Into a 50-mL pressure tank reactor (10 atm), was placed 3-[4-bromo-3-(2,2,2-trifluoroethyl)phenyl]-5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole (600 mg, 1.08 mmol, 1.00 equiv), ethanol (20 mL), Pd(dppf)Cl2 (158 mg, 0.22 mmol, 0.20 equiv), NaOAc (177 mg, 2.16 mmol, 2.00 equiv), CO (10 atm). The resulting solution was stirred overnight at 110° C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:30-1:10). This resulted in 300 mg (46%) of ethyl 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-(2,2,2-trifluoroethyl)benzoate as yellow oil.
WORKUP
后处理
- customInto a 50-mL pressure tank reactor (10 atm), was placed
- concentrationThe resulting mixture was concentrated under vacuum
- customThis resulted in 300 mg (46%) of ethyl 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-(2,2,2-trifluoroethyl)benzoate as yellow oil