dichloro(1,2-diaminocyclohexane) platinum(II) → Cyclohexane-1(R),2(R)-diamine-platinum(II)

HRID 638653Notes

Reaction equation

HRID 638653 reaction equation
[Pt+2:1].Cl[C:3]1([NH2:11])[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1(Cl)[NH2:9]>P(OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)C[C@@H]1O)([O-])([O-])=O.[Ag+].[Ag+].O>[Pt+2:1].[NH2:9][C@@H:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@H:3]1[NH2:11]

Participants

4

Reactant 1

HCID 22998366dichloro(1,2-diaminocyclohexane) platinum(II)

Product 1

HCID 447833Cyclohexane-1(R),2(R)-diamine-platinum(II)

Reagents, catalysts & solvents 2

HCID 86740579Disilver thymidine monophosphateCatalystHCID 962WaterSolvent

Procedure

A mixture of dichloro(1,2-diaminocyclohexane) platinum(II) (760 mg) and 1.08 g of disilver thymidine monophosphate was suspended in 30 ml. of water. The reaction mixture was stirred in the dark at room temperature for 36 hours and then evaporated to dryness. The title product obtained (698 mg) was a white material that is water-soluble but alcohol-insoluble. When tested in the TLC systems indicated below, the following Rf values were obtained:

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-e173fdd259ed4a8795cf7dd772a00175
Source dataset
uspto-grants-1985_12
Patent number
US04562275

Reaction notes

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